Background: Mitochondrial dysfunction is linked to myocardial ischemia-reperfusion (I/R) injury. Checkpoint kinase 1 (CHK1) could facilitate cardiomyocyte proliferation and cardiac repair post ...

In humans, the main molecular energy carrier is adenosine triphosphate (ATP). It is critical for cellular functions all over ...

is an innovative strategy for the treatment of mitochondrial dysfunction such as cardiac ischemic reperfusion injuries, traumatic brain and spinal cord injuries, cerebral stroke, and neurodegenerative ...

Proteomic analysis demonstrated that acute myocardial ischemia-reperfusion (I/R) injury triggers extensive crotonylation, specifically of proteins associated with cardiomyocyte contractility, ...

Many of us remember from high school biology class that mitochondria are the cell’s “power plants.” These small kidney-bean-shaped structures are what convert nutrients from food into ATP ...

The antioxidant effect of the ACE inhibitor captopril has also been evaluated in a rat ischemia-reperfusion model. Both captopril and prazosin decreased lipid peroxidation in this model ...

(Mainichi/Koichiro Tezuka) OSAKA -- Ischemic heart disease accounts for about 5% of deaths in Japan, including that of famous actor Toshiyuki Nishida, who passed away on Oct. 17 at 76. The ...

Several observations from preclinical and short-term clinical studies support a role for sildenafil in the treatment of heart failure patients. The following discussion briefly considers each of ...

Ischemic strokes account for 71% of all stroke incidences globally. The foremost approach to treating ischemic stroke prioritizes quick reperfusion, involving methods such as intravenous thrombolysis ...