1). There are two major apoptotic pathways known to date, initiated by either the mitochondria (the 'intrinsic' pathway) or the cell surface receptors (the 'extrinsic' pathway). Mitochondria ...
Using stem cell-derived artificial organelles to improve neural oxidative phosphorylation imbalances
In humans, the main molecular energy carrier is adenosine triphosphate (ATP). It is critical for cellular functions all over ...
Underlying mechanisms of ketotherapy in heart failure: current evidence for clinical implementations
2023). This study revealed that H3K27me2 and H3K36me1, which are specifically upregulated histone modifications in ischemic heart failure, are sensitive to β-HB levels. The increase in H3K27me2 and ...
More than 200 million people worldwide have peripheral artery disease (PAD). PAD affects the quality of life and is associated with significant morbidity and mortality. Standard treatment for severe ...
(Mainichi/Koichiro Tezuka) OSAKA -- Ischemic heart disease accounts for about 5% of deaths in Japan, including that of famous actor Toshiyuki Nishida, who passed away on Oct. 17 at 76. The ...
is recognized for its diverse biological functionalities, in particular alleviating myocardial ischemia-reperfusion injury (MIRI). There is ample evidence suggesting that the NLRP3 inflammasome has a ...
is an innovative strategy for the treatment of mitochondrial dysfunction such as cardiac ischemic reperfusion injuries, traumatic brain and spinal cord injuries, cerebral stroke, and neurodegenerative ...
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