Secretary of State Marco Rubio embarks soon on his inaugural trip as the United States’ top diplomat. His first stop, Panama could prove to be the most contentious on the itinerary.

Panamanian President Jose Raul Mulino on Thursday ruled out discussing control over the Panama Canal in a meeting with U.S. Secretary of State Marco Rubio, who is set to visit the Central American country in his first official trip abroad this weekend.

Panama President José Raúl Mulino said Thursday there will be no negotiation with the United States over ownership of the Panama Canal, and he hopes U.S. Secretary of State Marco Rubio’s upcoming visit will allow them to focus on shared interests including migration and combating drug trafficking.