Disease-causing mutations in the signaling protein BMP4 impair its secretion, but only when it is made as a homodimer.

This valuable study provides insights into a key question in comparative neuroanatomy and development. The authors provide evidence of the role for a particular micro-RNA in regulating the development ...

Microfluidics experiments and simulations show that magnetotactic bacteria are adapted to the geomagnetic field strength for optimal navigation in sediment environments.

This useful study explores the role of RAP2A in asymmetric cell division (ACD) regulation in glioblastoma stem cells (GSCs), drawing parallels to Drosophila ACD mechanisms and proposing that an ...

(NEPC). The findings enhance the understanding of the treatment of androgen receptor functions in NEPC. Neuroendocrine prostate cancer (NEPC) arises primarily through neuroendocrine ...

BP1 is a key player in DNA repair and together with BRCA1 regulate selection of DNA double strand break repair mechanisms. Localization of DNA repair factors to sites of DNA damage by 53BP1 is ...

A new study finds that nocebo effects, where people expect a negative outcome from treatment, are more powerful and persistent than placebo effects, with implications for patient-practitioner ...

Researchers have shown that activation of the protein YAP, which helps tumours grow, differs between two- and three-dimensional culture models, pointing to more predictive systems for testing cancer ...

This important study provides compelling insights into the differential impact of intrinsic and synaptic conductances on circuit robustness using computational models of the pyloric network from the ...

This study presents a valuable finding on the role of secretory leukocyte protease inhibitors (SLPI) in developing Lyme disease in mice infected with Borrelia burgdorferi. The evidence supporting the ...

Version of Record: This is the final version of the article. The paper by Fournier et al. investigates the sensitivity of neural circuits to changes in intrinsic and synaptic conductances. The authors ...

Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...