Glucagon-like peptide-1 - Wikipedia
Glucagon-like peptide-1 (GLP-1) is a 30- or 31-amino-acid-long peptide hormone deriving from the tissue-specific posttranslational processing of the proglucagon peptide. It is produced and secreted by intestinal enteroendocrine L-cells and certain neurons within the nucleus of the solitary tract in the brainstem upon food consumption.
GLP-1 Agonists: What They Are, How They Work & Side Effects
Glucagon-like peptide-1 agonists. GLP-1 receptor agonists. Incretin mimetics. GLP-1 analogs. These medications are relatively new. The U.S. Food and Drug Administration (FDA) approved the first GLP-1 agonist (exenatide) in 2005. Researchers are still learning about their other potential uses and benefits.
Glucagon-Like Peptide-1 Receptor Agonists - StatPearls - NCBI Bookshelf
Feb 29, 2024 · Glucagon-like peptide-1 (GLP-1) agonists are a class of medications utilized to treat type 2 diabetes mellitus (T2DM) and obesity. As a class of medications, they are among several pharmacological options for these endocrine diseases.
Glucagon-like peptide 1 (GLP-1) - PMC - PubMed Central (PMC)
The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose-dependent stimulation of insulin secretion, decrease of gastric emptying, inhibition of food intake, increase of natriuresis and diuresis, and modulation of rodent β-cell proliferation.
Glucagon-like peptide 1 (GLP-1) - PubMed
Since its discovery, GLP-1 has emerged as a pleiotropic hormone with a myriad of metabolic functions that go well beyond its classical identification as an incretin hormone. The numerous beneficial effects of GLP-1 render this hormone an interesting candidate for the development of pharmacotherapies …
Glucagon-like peptide 1 | Hormones
What is glucagon-like peptide 1? Glucagon-like peptide 1 belongs to a family of hormones called the incretins, so-called because they enhance the secretion of insulin due to factors derived from the gut. Glucagon-like peptide 1 is a product of a molecule called pre-proglucagon, a polypeptide (i.e. chain of amino acids, which are organic ...
The physiology of glucagon-like peptide 1 - PubMed
Glucagon-like peptide 1 (GLP-1) is a 30-amino acid peptide hormone produced in the intestinal epithelial endocrine L-cells by differential processing of proglucagon, the gene which is expressed in these cells.
Glucagon-like peptide-1 receptor: mechanisms and advances in …
Sep 18, 2024 · The glucagon-like peptide-1 (GLP-1) receptor, known as GLP-1R, is a vital component of the G protein-coupled receptor (GPCR) family and is found primarily on the surfaces of various cell types...
How glucagon-like peptide 1 receptor agonists work - PMC
In recent years, glucagon-like peptide 1 receptor agonists (GLP-1RAs) have become central in the treatment of type 2 diabetes (T2D). In addition to their glucose-lowering properties with low risk of hypoglycaemia, GLP-1RAs reduce body weight and ...
Metabolic Messengers: glucagon-like peptide 1 - Nature
Jan 11, 2021 · Glucagon like peptide-1 (GLP-1), a peptide hormone from the intestinal tract, plays a central role in the coordination of postprandial glucose homeostasis through actions on insulin secretion...