Protein C inhibitor - Wikipedia
Protein C inhibitor (PCI, SERPINA5) is a serine protease inhibitor that limits the activity of protein C (an anticoagulant). An N-terminal fragment of PCI is a possible serum biomarker for prostate cancer .
Protein C inhibitor - PubMed
Protein C inhibitor (PCI) is a serine protease inhibitor and was originally identified as an inhibitor of activated protein C (APC). However, PCI is not specific for APC and also inhibits several proteases involved in coagulation, fibrinolysis, cancer, wound healing, and fertility.
Regulation of Blood Coagulation by the Protein C ...
Apr 28, 2005 · Activated protein C (APC) together with its cofactor protein S inhibits coagulation by degrading FVIIIa and FVa on the surface of negatively charged phospholipid membranes.
Protein C Inhibitor Acts as a Procoagulant by Inhibiting the ...
Mar 1, 1998 · Protein C inhibitor (PCI), which was originally identified as an inhibitor of activated protein C, also efficiently inhibits coagulation factors such as factor Xa and thrombin. Recently it was found, using purified proteins, that the anticoagulant thrombin-thrombomodulin complex was also inhibited by PCI.
Protein C Inhibitor - an overview | ScienceDirect Topics
Protein C inhibitor is a nonspecific serine protease inhibitor secreted from activated platelet particles at plasma concentrations of 80–100 nM [74]. In coagulation, Protein C inhibitor has both procoagulant and anticoagulant properties, whose main targets are thrombin and activated protein C …
The Protein C Pathway - CHEST
The protein C anticoagulant pathway serves as a major system for controlling thrombosis, limiting inflammatory responses, and potentially decreasing endothelial cell apoptosis in response to inflammatory cytokines and ischemia.
Protein C anticoagulant and cytoprotective pathways - PMC
The known inhibitors of APC in plasma include protein C inhibitor (PCI), α 1-antitrypsin, α 2-macroglobulin and α 2-antiplasmin. Protein C is homologous to the vitamin K-dependent coagulation factors VII, IX, and X and the protein C gene (PROC) is comprised of nine exons and eight introns, located on chromosome 2q13–14 [ 18 , 19 ].