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How Tranexamic Acid (TXA) Stops Bleeding: The Mechanism of Action
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🩸 Tranexamic Acid (TXA) – How does it actually work? When trauma patients bleed, their body forms clots to stop the loss. But the body also activates fibrinolysis – the natural breakdown of clots. In major haemorrhage this can become overactive, leading to clot breakdown before bleeding is controlled. 👉 TXA works by blocking plasminogen from converting into plasmin, the enzyme that dissolves fibrin clots. 👉 This helps stabilise clots, reduce bleeding, and improve survival if given within 3 ho
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